Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration

Fahey JW, Wade KL, Stephenson KK, Panjwani AA, Liu H, Cornblatt G, Cornblatt BS, Ownby SL, Fuchs E, Holtzclaw WD, Cheskin LJ · Nutrients

Sulforaphane yield depends on stomach chemistry as well as on the food: adding myrosinase to the preparation raises conversion, and altering gastric acid with a proton pump inhibitor changes the amount absorbed.

Population

Healthy adults given glucoraphanin-rich broccoli sprout and seed extracts with active myrosinase, with and without a proton pump inhibitor

Intervention

Broccoli sprout/seed extract with active myrosinase

Comparator

The same extract during proton-pump-inhibitor treatment

Limitations

Pilot study, small, healthy volunteers, no joint endpoint. Several authors have commercial interests in broccoli-sprout preparations.