Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

Biver E, Berenbaum F, Valdes AM, Araujo de Carvalho I, Bindels LB, Brandi ML, Calder PC, Castronovo V, Cavalier E, Cherubini A, Cooper C, Dennison E, Franceschi C, Fuggle N, Laslop A, Miossec P, Thomas T, Tuzun S, Veronese N, Vlaskovska M, Reginster JY, Rizzoli R · Ageing Research Reviews

The reference statement for how seriously to take this field. It sets out the metabolic-endotoxaemia hypothesis linking obesity, gut permeability and low-grade joint inflammation, and concludes that the evidence in humans is at the association and mechanism stage rather than the intervention stage.

Population

The gut-microbiota-and-osteoarthritis literature, appraised by an ESCEO expert working group

Intervention

Microbiota-targeted approaches — prebiotics, probiotics, diet

Comparator

Not applicable

Limitations

Expert consensus, not a systematic review, and several authors of ESCEO statements hold industry relationships in the osteoarthritis field.