Effect of Betaine on Reducing Body Fat-A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Gao X, Zhang H, Guo XF, Li K, Li S, Li D · Nutrients

Pooled body fat mass fell 2.53 kg (95% CI -3.93 to -0.54) and body fat percentage 2.44% (95% CI -4.20 to -0.68), while body weight and BMI did not change — fat lost without the scale moving, across a small evidence base.

Population

Adults across 6 randomised controlled trials

Intervention

Betaine supplementation

Comparator

Placebo

Limitations

Six trials totalling 195 participants; wide confidence intervals; body-composition methods differ between trials; no clinical or joint endpoint.