Short Peptides Protect Oral Stem Cells from Ageing

Sinjari B, Diomede F, Khavinson V, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S · Stem Cell Reviews and Reports

AEDG cut p16 and p21 mRNA by 1.56–2.44-fold and KED by 1.82–3.23-fold against control, confirmed by immunofluorescence — the program's peptides tested in a Western laboratory, at the University of Chieti-Pescara.

Population

Human periodontal-ligament and gingival mesenchymal stem cells at passage 25

Intervention

AEDG and KED peptides added to the culture medium

Comparator

Untreated cells at the same passage

Limitations

Khavinson and two institute colleagues are co-authors, so this is a collaboration rather than an independent replication; senescence markers in culture, and neither peptide is the AED tripeptide.