Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+

Maquart FX, Pickart L, Laurent M, et al. · FEBS Letters

Stimulated collagen synthesis from picomolar concentrations, maximal around 10^-9 M, independent of proliferation.

Population

Cultured human dermal fibroblasts

Intervention

GHK-Cu at 10^-12 to 10^-7 M

Comparator

Untreated cultures

Limitations

Skin fibroblasts, not chondrocytes or tenocytes; mechanism study only.