Electrospun thymosin Beta-4 loaded PLGA/PLA nanofiber/microfiber hybrid yarns for tendon tissue engineering application

Wu S, Zhou R, Zhou F, Streubel PN, Chen S, Duan B · Materials Science and Engineering C

Tβ4 release added to the scaffold's effect on stem-cell migration, proliferation and tendon-lineage gene expression, and in plain culture raised proliferation and tendon-marker expression with dose — an additive, not a standalone, tenogenic signal.

Population

Human adipose-derived mesenchymal stem cells on aligned electrospun yarns

Intervention

Tβ4 released from PLGA/PLA hybrid yarns over 28 days (18.5 and 190.7 ng per mg of nanofibre at two loadings); 10 to 1,000 ng/mL in plain culture

Comparator

Yarns without Tβ4

Limitations

Cell culture on a material; no implanted tendon, no mechanical healing outcome. NIH and Nebraska state funding with Chinese science-and-technology grants; no competing interest.