Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes

Khavinson VK, Pendina AA, Efimova OA, Tikhonov AV, Koltsova AS, Krapivin MI, Petrovskaia-Kaminskaia AV, Petrova LI, Lin'kova NS, Baranov VS · Bulletin of Experimental Biology and Medicine

Relative telomere length changed significantly in 7 of 11 donors — up in 5 (by 18–156%) and down in 2 (by 15% and 37%) — with the direction tracking whether the donor started below or above the group mean. The mitotic index was essentially unchanged.

Population

PHA-stimulated blood lymphocytes from 5 men aged 18–22 and 6 aged 49–54

Intervention

Peptide AEDG in culture

Comparator

Untreated cultures from the same donors

Limitations

Eleven donors, cells in culture rather than dosed people, and effects in both directions; a different peptide from Cartalax; institute-authored.