The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial

Hashemzadeh K, Davoudian N, Jaafari MR, Mirfeizi Z · Current Rheumatology Reviews

Total WOMAC and the pain, stiffness and physical-activity subscales all improved versus placebo at 6 weeks at a curcumin dose of 80 mg/day.

Population

Adults with knee osteoarthritis, Iran

Intervention

Nanomicelle curcumin 40 mg every 12 hours for 6 weeks

Comparator

Placebo containing the same nanomicelle carrier without curcumin

Limitations

n=71, 6 weeks, single centre; the carrier-matched placebo is a design strength, but no structural or biomarker endpoint was measured.