Intragastric Application of Aspirin, Clopidogrel, Cilostazol, and BPC 157 in Rats: Platelet Aggregation and Blood Clot

Konosic S, Petricevic M, Ivancan V, Drmic D, Seiwerth S, Sikiric P, et al. · Oxidative Medicine and Cellular Longevity

BPC 157 restored platelet aggregation that aspirin, clopidogrel and cilostazol had suppressed — arachidonic-acid, ADP and collagen-induced aggregation all recovered — while thromboelastometry measures of clot formation and lysis were unchanged.

Population

Rats given aspirin, clopidogrel or cilostazol 10 mg/kg intragastrically for three days

Intervention

BPC 157 10 µg/kg intragastrically after each antiplatelet dose

Comparator

Antiplatelet plus saline

Limitations

Originating network, rat aggregometry; reported as a benefit, but reversal of an intended antiplatelet effect is a drug-interaction signal for anyone taking aspirin or clopidogrel, and it has never been tested in humans.