AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism

Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B · Molecules

The neurogenic differentiation markers Nestin, GAP43, beta-tubulin III and doublecortin rose 1.6 to 1.8-fold at the mRNA level with matching protein by immunofluorescence. Molecular modelling proposed binding to the DNA-interacting sites of histones H1/3 and H1/6 as an epigenetic mechanism.

Population

Human gingival mesenchymal stem cells at third passage

Intervention

AEDG 0.01 µg/ml in the medium, replaced every 3 days, for 7 days

Comparator

Untreated cultures

Limitations

Institute and Chieti collaboration with Khavinson as first author; no external funding. The histone-binding mechanism is a docking model, not a measurement. One of the two epithalon sources the 2026 JAAOS orthopaedic review cites.