Enhanced biological properties of collagen/chitosan-coated poly(ε-caprolactone) scaffold by surface modification with GHK-Cu peptide and 58S bioglass

Molavi AM, Sadeghi-Avalshahr A, Nokhasteh S, Naderi-Meshkin H · Progress in Biomaterials

GHK-Cu-coated scaffolds raised cell proliferation significantly at days 3 and 7 and showed the strongest antibacterial activity of the surfaces tested, with cell attachment comparable across all groups.

Population

Electrospun poly(ε-caprolactone) scaffolds coated with collagen/chitosan

Intervention

Surface modification with 1 mM GHK-Cu, or with 58S bioactive glass

Comparator

Uncoated collagen/chitosan-coated scaffold

Limitations

Materials-science characterisation with viability and antibacterial assays; no differentiation, matrix or animal endpoint.