Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J · The American Journal of Clinical Nutrition

Fat-free mass rose slightly (62.7% versus 61.3%, p=0.02) and muscle acetylcarnitine rose (4,558 versus 3,025 pmol/mg dry weight, p=0.04), with a higher sleeping metabolic rate. Insulin sensitivity, mitochondrial function, liver and muscle lipid, cardiac energy status, blood pressure and inflammation markers were all unchanged.

Population

Healthy overweight or obese men and women

Intervention

Nicotinamide riboside 1,000 mg/day for 6 weeks, crossover

Comparator

Placebo

Limitations

Thirteen participants; the positive findings are small and mechanistic while every clinically meaningful endpoint was null.