The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

Chin KY · Nutrients

Concludes sufficient vitamin K status is consistently associated with lower risk of OA and pathological joint features via activation of calcification inhibitors (MGP), but that interventional trial evidence remains limited and largely null on primary endpoints.

Population

Narrative review of observational and trial data on vitamin K and OA

Intervention

Dietary and supplemental vitamin K (K1 and K2)

Comparator

n/a

Limitations

Narrative (not systematic) review; cannot add evidence beyond the underlying observational studies.