Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial

Sit RWS, Wu RWK, Rabago D, et al. · Annals of Family Medicine

WOMAC pain improved by an additional -10.34 points (95% CI -19.20 to -1.49, P=.022) vs saline at 52 weeks, with favorable effects on function and quality of life. No adverse events reported.

Population

76 adults with knee OA in Hong Kong primary care

Intervention

Intra-articular hypertonic dextrose at weeks 0, 4, 8, 16

Comparator

Normal saline on the same schedule (blinded)

Limitations

Modest sample; saline itself may have mild lavage effects; replication by the same collaborators as the 2013 trial.