Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran

Atabaki M, Shariati-Sarabi Z, Tavakkol-Afshari J, Mohammadi M · International Immunopharmacology

VAS and CRP fell, CD4+, CD8+, Th17 and B-cell frequencies dropped and regulatory T cells rose, shifting the Treg/Th17 ratio toward Treg.

Population

Adults meeting ACR criteria for osteoarthritis, Iran

Intervention

SinaCurcumin nanomicelle 80 mg daily for 3 months

Comparator

Placebo

Limitations

n=30 split into two arms — the smallest curcumin osteoarthritis trial here; mechanistic immune endpoints with no structural measure, single centre.