The Effects of Vitamin D and Marine Omega-3 Fatty Acid Supplementation on Chronic Knee Pain in Older US Adults: Results From a Randomized Trial

MacFarlane LA, Cook NR, Kim E, et al. · Arthritis & Rheumatology

NULL: WOMAC knee pain did not differ between vitamin D and placebo at any point over ~5 years (treatment-by-time P=0.41); omega-3 was also null.

Population

VITAL trial participants with chronic knee pain (from 25,871 randomized), mean follow-up 5.3 years

Intervention

Vitamin D3 2000 IU/day (2x2 factorial with 1 g/day marine omega-3)

Comparator

Placebo

Limitations

Knee-pain cohort is a subgroup of a general-population trial; no imaging; participants not selected for deficiency or radiographic OA.