The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies

Kang D, Lee J, Wu C, Guo X, Lee BJ, Chun JS, Kim JH · Experimental & Molecular Medicine

Supplies the mechanism the epidemiology needs. Selenium's biological function runs through selenoproteins — principally the glutathione peroxidases and thioredoxin reductases that handle oxidative stress — and several are expressed in chondrocytes, which makes a deficiency disease of cartilage biologically coherent rather than merely geographic.

Population

Selenoprotein biology in cartilage

Intervention

Not applicable

Comparator

Not applicable

Limitations

Mechanistic review. It explains why selenium could matter to cartilage; it does not show that varying intake within a replete population does.