Hydrogels based on low-methoxyl amidated citrus pectin and flaxseed gum formulated with tripeptide glycyl-l-histidyl-l-lysine improve the healing of experimental cutting wounds in rats

Synytsya A, Poučková P, Zadinová M, Troshchynska Y, Štětina J, Synytsya A, Saloň I, Král V · International Journal of Biological Macromolecules

GHK in either hydrogel produced a significantly higher healing degree and shorter healing time than untreated wounds or the same peptide in aqueous solution. Complete healing on histology was reached only with the flaxseed-gum formulation, and adding arginine gave no synergy.

Population

Rats with experimental cutting wounds and extensive skin damage

Intervention

GHK delivered in citrus-pectin or flaxseed-gum hydrogels, alone or with α-L-arginine

Comparator

GHK in aqueous solution, and untreated wounds

Limitations

Dermal model; the headline comparison is formulation, and the aqueous-GHK arm underperforming both gels bounds what free peptide achieves.