Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial

Thomas JV, Smina TP, Khanna A, Kunnumakkara AB, Maliakel B, Mohanan R, Krishnakumar IM · Phytotherapy Research

The low-dose curcumin complex improved VAS by 47.0%, walking performance by 206% and total WOMAC by 35% from baseline, which the authors report as superior to the glucosamine-chondroitin comparator.

Population

Adults with knee osteoarthritis, India

Intervention

Curcumagalactomannoside (CurQfen) 400 mg once daily for 6 weeks

Comparator

Glucosamine hydrochloride 500 mg plus chondroitin sulphate 415 mg twice daily

Limitations

Open-label with no placebo arm, 6 weeks, n=72; conducted and authored by the ingredient manufacturer (Akay), and the comparator is itself a weakly evidenced supplement, so 'superior' is a low bar.