Comparison of the Effects of KE and AED Peptides on Functional Activity of Human Skin Fibroblasts during Their Replicative Aging

Fridman NV, Linkova NS, Kozhevnikova EO, Gutop EO, Khavinson VK · Bulletin of Experimental Biology and Medicine

AED raised synthesis of sirtuin-1, sirtuin-6 and type I collagen in aging fibroblasts; KE lowered IL-1, NF-kappaB and TGF-beta and raised sirtuin-6. Type I collagen is the skin isoform, not the type II collagen of articular cartilage.

Population

Human skin fibroblasts in a replicative-aging model

Intervention

AED (Cartalax) and KE (Vilon) peptides

Comparator

Untreated aging cultures

Limitations

Immunocytochemistry with confocal microscopy and no numbers in the indexed abstract; skin fibroblasts, not chondrocytes; institute-authored.