NAD(+) metabolism and its roles in cellular processes during ageing

Covarrubias AJ, Perrone R, Grozio A, Verdin E · Nature Reviews Molecular Cell Biology

Narrative synthesis of NAD+ biology in ageing: the salvage pathway and its rate-limiting enzyme NAMPT, the three consumer families (sirtuins, PARPs, CD38/CD157), and the evidence that tissue NAD+ falls with age through both reduced synthesis and increased consumption.

Limitations

Narrative review, not a systematic one; several authors have commercial interests in NAD+ precursor development.