NAD(+) metabolism and its roles in cellular processes during ageing

Covarrubias AJ, Perrone R, Grozio A, Verdin E · Nature Reviews Molecular Cell Biology

Narrative synthesis of NAD+ biology in ageing: the salvage pathway and its rate-limiting enzyme NAMPT, the consumer families (sirtuins, PARPs, CD38/CD157 and, more recently assigned, SARM1), and the evidence that tissue NAD+ falls with age through both reduced synthesis and increased consumption. Whether SARM1 regulates NAD+ under physiological conditions, and how much, the review states as still unknown.

Limitations

Narrative review, not a systematic one. The review was funded by the NIH and Buck Institute intramural funds, and three of its four authors declare commercial interests in the field it covers: a scientific co-founder of one NAD+ company who also advises a second, a chief scientific officer of that second company who is an inventor on the SLC12A8 NMN-transporter patent, and research support from both companies.