Intra-Articular Injection of (-)-Epigallocatechin 3-Gallate to Attenuate Articular Cartilage Degeneration by Enhancing Autophagy in a Post-Traumatic Osteoarthritis Rat Model

Huang HT, Cheng TL, Ho CJ, Huang HH, Lu CC, Chuang SC, Li JY, Lee TC, Chen ST, Lin YS, Lee CY, Kang L, Lin SY, Chen CH · Antioxidants (Basel)

Less cartilage degeneration, attributed to enhanced chondrocyte autophagy. Included alongside the mouse work because both routes that produce a result — intraperitoneal and intra-articular — bypass the gut.

Population

Rats with post-traumatic osteoarthritis

Intervention

EGCG injected into the joint

Comparator

Vehicle injection

Limitations

Injected into the joint. It says nothing about drinking tea.