Clopidogrel-Induced Gastric Injury in Rats is Attenuated by Stable Gastric Pentadecapeptide BPC 157

Wu H, Wei M, Li N, Lu Q, Shrestha SM, Tan J, Zhang Z, Wu G, Shi R · Drug Design, Development and Therapy

Clopidogrel drove ulcer recurrence, ER-stress apoptosis (CHOP) and inflammation while suppressing VEGF-A, VEGFR1 and eNOS; BPC 157 reversed each of those, and L-NAME blunted the protection — nitric-oxide dependence demonstrated by a group with no connection to the originating laboratory.

Population

Sprague-Dawley rats with healed acetic-acid gastric ulcers, then given clopidogrel

Intervention

BPC 157 with clopidogrel, with or without L-NAME

Comparator

Clopidogrel alone; methylcellulose control

Limitations

Single independent replication of the NO-dependence claim, in a drug-injury rather than a healing model.