Long-term Prospective Clinical and Magnetic Resonance Imaging-Based Evaluation of Matrix-Induced Autologous Chondrocyte Implantation

Ebert JR, Fallon M, Wood DJ, Janes GC · The American Journal of Sports Medicine

Patient-reported outcomes remained significantly improved at 10-16 years; 9.1% of grafts failed; 88.5% of patients satisfied. MRI tissue infill showed a nonsignificant decline from 2 years to final review.

Population

87 patients (99 MACI grafts) followed prospectively for a minimum of 10 years (mean 13.1)

Intervention

MACI

Comparator

None

Limitations

Uncontrolled single-group cohort; the durability signal beyond RCT horizons rests on series like this, not randomized data.