Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy

Bansal H, Leon J, Pont JL, et al. · Scientific Reports

WOMAC, IKDC and 6-minute walk improvements persisted in the PRP group at 12 months while the HA group's gains faded; authors argue ~10 billion platelets is the threshold for sustained effect.

Population

Adults with moderate knee OA

Intervention

Single PRP injection with an absolute dose of 10 billion platelets

Comparator

Hyaluronic acid

Limitations

Open comparison against HA, not saline; single center; dose threshold inferred, not tested across randomized dose arms. A published author correction exists (PMID 34521970).