Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Yoshino M, Yoshino J, Kayser BD, et al. · Science

NMN increased skeletal-muscle insulin sensitivity and insulin signalling; no joint or cartilage outcomes were measured — cited here as the benchmark human-efficacy NMN trial, not as joint evidence.

Population

Postmenopausal women with prediabetes and overweight/obesity

Intervention

NMN 250 mg/day for 10 weeks

Comparator

Placebo

Limitations

Small; single metabolic endpoint population; several other NMN metabolic endpoints in the same trial were unchanged; nothing measured in joints.