Dietary Oleocanthal Supplementation Prevents Inflammation and Oxidative Stress in Collagen-Induced Arthritis in Mice

Montoya T, Sánchez-Hidalgo M, Castejón ML, Rosillo MÁ, González-Benjumea A, Alarcón-de-la-Lastra C · Antioxidants (Basel)

Fed rather than injected, which is the point. The diet prevented bone, joint and cartilage damage, lowered circulating MMP-3 and IL-6, IL-1β, TNF-α, IL-17 and IFN-γ, and reduced COX-2, mPGES-1, iNOS and PGE2, apparently through Nrf-2/HO-1 activation with suppression of JAK-STAT, MAPK and NF-κB.

Population

Mice with collagen-induced arthritis

Intervention

Oleocanthal-enriched diet, started 6 weeks before immunization and continued to day 43

Comparator

Standard diet

Limitations

Collagen-induced arthritis is an autoimmune model closer to rheumatoid than to osteoarthritis, and the diet was preventive — started six weeks before disease was induced.