Sulforaphane protects against oxidative stress-induced apoptosis via activating SIRT1 in mouse osteoarthritis

Chen M, Huang L, Lv Y, Li L, Dong Q · Molecular Medicine Reports

Reduced chondrocyte apoptosis under oxidative stress, and silencing SIRT1 removed the protection; in the mice OARSI and synovitis scores were lower with treatment. A third proposed mechanism alongside NF-κB inhibition and the Nrf2 pathway, which is a sign the target is not yet settled.

Population

Mouse chondrocytes under hydrogen peroxide stress, and mice with surgically destabilised menisci

Intervention

Sulforaphane at 50 μM in cells; 20 mg/kg by intraperitoneal injection every 2 days for 8 weeks in the mice

Comparator

Untreated

Limitations

Mouse and cell work, 15 mice per group, and the compound was injected into the abdomen rather than eaten. The abstract describes a hydrogen-peroxide mouse model that the methods do not contain; the mice had surgical destabilisation. Funded by provincial and hospital grants.