Sulforaphane protects against oxidative stress-induced apoptosis via activating SIRT1 in mouse osteoarthritis

Chen M, Huang L, Lv Y, Li L, Dong Q · Molecular Medicine Reports

Reduced chondrocyte apoptosis through SIRT1 activation — a third proposed mechanism alongside NF-κB inhibition and the Nrf2 pathway, which is a sign the target is not yet settled.

Population

Mouse osteoarthritis model and chondrocytes under oxidative stress

Intervention

Sulforaphane

Comparator

Untreated

Limitations

Mouse and cell work; mechanism inferred from pathway inhibition.