Bone Marrow Aspirate Concentrate for the Treatment of Knee Osteoarthritis: A Systematic Review

Keeling LE, Belk JW, Kraeutler MJ, et al. · The American Journal of Sports Medicine

94% of reported outcome measures improved from baseline, but BMAC demonstrated no clinical superiority over PRP, microfragmented adipose tissue, or placebo in any comparative study.

Population

8 studies, 299 knees, mean follow-up 12.9 months

Intervention

Intra-articular BMAC

Comparator

Various (PRP, MFAT, placebo, baseline)

Limitations

Level 4 evidence pool; heterogeneous preparation protocols; improvement-from-baseline dominates the literature.