Response to Comment on "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women"

Klein S, Yoshino M · Science

The trial authors reply that muscle insulin sensitivity — the primary outcome — was identical in both arms at baseline and improved only on NMN, and that a baseline difference in liver fat does not negate an effect measured in muscle.

Limitations

Correspondence. The exchange stands unresolved; the trial has not been replicated at this endpoint.