Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen

Nagler-Anderson C, Bober LA, Robinson ME, et al. · Proceedings of the National Academy of Sciences of the United States of America

Oral native type II collagen suppressed the incidence and severity of collagen-induced arthritis, the foundational demonstration of the oral-tolerance mechanism invoked for UC-II.

Population

Mice with collagen-induced arthritis

Intervention

Intragastric (oral) soluble native type II collagen before arthritis induction

Comparator

Untreated / denatured collagen controls

Limitations

Mouse autoimmune-arthritis model; does not establish efficacy in human osteoarthritis.