Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone

Yajun W, et al. · Frontiers in Pharmacology

Betaine reduced cartilage proteoglycan loss, lowered OARSI histology scores, decreased MMP-13/collagen-X-positive cells and normalised subchondral bone remodelling and aberrant angiogenesis, apparently via ROS/MAPK-dependent inhibition of osteoclastogenesis.

Population

Mice with surgically induced (ACLT) knee OA; osteoclast cultures

Intervention

Betaine treatment after OA induction

Comparator

Untreated ACLT mice

Limitations

Mouse surgical-OA model; abstract does not state dose or group sizes; no human data.