Ternary Cu(2+) Complexes of Human Serum Albumin and Glycyl-l-histidyl-l-lysine

Bossak-Ahmad K, Bal W, Frączyk T, Drew SC · Inorganic Chemistry

Two ternary Cu(GHK)-albumin complexes form through histidine imino nitrogens, one at His3 (conditional constant 2900 M⁻¹) and a second at His128 or His510 (1700 M⁻¹). GHK is most concentrated in the albumin-rich plasma fraction, and these complexes give a physical route by which it could shuttle the exchangeable copper pool.

Population

Human serum albumin and GHK in solution at pH 7.4

Intervention

Spectroscopic characterisation of ternary Cu(2+) complexes

Comparator

Binary Cu-GHK and Cu-albumin complexes

Limitations

Solution chemistry. It establishes that the complexes can exist, not that they carry copper to any tissue in vivo.