Analysis of the Anti-Inflammatory Capacity of Bone Broth in a Murine Model of Ulcerative Colitis

Mar-Solís LM, Soto-Domínguez A, Rodríguez-Tovar LE, et al. · Medicina (Kaunas)

Bone broth reduced colonic pro-inflammatory cytokine expression (IL-6 down ~95%, IL-1beta down ~61%, TNF-alpha down ~69%) and raised anti-inflammatory IL-10 and IL-4. A gut-inflammation model — not a joint or cartilage outcome.

Population

BALB/c mice with chemically induced ulcerative colitis

Intervention

Prophylactic oral bone broth before colitis induction

Comparator

Colitis controls without broth

Limitations

Mouse colitis model; nothing to do with cartilage or joints; single study; broth composition poorly standardized.