Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study

Zhang Y, Fan J, Chen L, Xiong Y, Wu T, Shen S, Wang X, Meng X, Lu Y, Lei X · Frontiers in Endocrinology

The earlier and independent version of the same analysis, reaching the same direction — genetically predicted coffee consumption associated with higher osteoarthritis risk across joint sites.

Population

GWAS summary data for coffee consumption against total, knee, hip and self-reported osteoarthritis

Intervention

Genetically predicted coffee consumption

Comparator

Lower genetically predicted consumption

Limitations

Shares the instrument and ancestry limitations of all coffee MR, and overlaps in GWAS sources with the later analyses, so the agreement between them is not full independence.