Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

Okabe K, Yaku K, Uchida Y, Fukamizu Y, Sato T, Sakurai T · Frontiers in Nutrition

Whole-blood NAD+ rose significantly against placebo with no abnormalities in physiological or laboratory tests. Blood NMN itself did not rise, while nicotinic acid mononucleotide did — a clue that oral NMN reaches NAD+ by an indirect route.

Population

Healthy adult volunteers

Intervention

NMN 250 mg/day for 12 weeks

Comparator

Placebo

Limitations

Fifteen per arm, healthy volunteers, biochemical endpoints only; no functional or clinical outcome was measured. Manufacturer-affiliated authorship.