Biomimetic Hydrogel Scaffolds with Copper Peptide-Functionalized RADA16 Nanofiber Improve Wound Healing in Diabetes

Yang X, Zhang Y, Huang C, Lu L, Chen J, Weng Y · Macromolecular Bioscience

Accelerated wound closure, more collagen deposition and greater tissue remodelling in both healthy and diabetic mice, with higher eNOS and CD31 on immunohistochemistry and more neovascularisation.

Population

Healthy and diabetic mice, with endothelial cells in vitro

Intervention

GHK-functionalised RADA16 self-assembling peptide nanofiber hydrogel chelating Cu(II)

Comparator

Unfunctionalised RADA16 hydrogel

Limitations

Dermal model with an engineered scaffold; the peptide is immobilised on nanofiber, not administered as GHK-Cu.