Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis

Liao Z, Chang J, Zhu Z, et al. · Arthritis Care & Research

Higher vitamin K intake tracked greater improvement in total WOMAC and dysfunction scores over 24 months, most clearly in those with severe baseline pain, but there was no overall association with MRI cartilage defects, bone marrow lesions or effusion-synovitis — symptoms moved and structure did not.

Population

Patients with symptomatic knee osteoarthritis, 212 followed for 2 years with MRI

Intervention

Baseline dietary vitamin K intake by validated food-frequency questionnaire

Comparator

Lower intake quartiles

Limitations

Observational with a single baseline questionnaire; the structural findings appear only in subgroups after multiple comparisons; food-frequency vitamin K is overwhelmingly K1, and dietary intake tracks overall diet quality.