Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy

Perovic D, Milavic M, Dokuzovic S, Seiwerth S, Sikiric P, et al. · Current Issues in Molecular Biology

Treated animals showed only discrete oedema and minimal haemorrhage at 30 min with raised Nos1, Nos2 and Nos3; started at day 4, oral therapy still recovered tail function and no demyelination was seen on Luxol fast blue — recovery from an established, not only a fresh, lesion.

Population

Rats with sacrocaudal (S2–Co1) compression injury and tail paralysis, treated at 10 min or at day 4

Intervention

BPC 157 2 µg/kg intraperitoneally at 10 min, 10 ng/kg intragastrically at day 4, or 10 µg/kg per-orally in drinking water from day 4 for one month

Comparator

Untreated injury

Limitations

Originating network; three sub-experiments with small groups reported together, and outcome scoring is descriptive. University of Zagreb grant, with a funding statement of no external funding.