Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol

Bai LB, Yau LF, Tong TT, Chan WH, Zhang W, Jiang ZH · Pharmacology Research & Perspectives

The only direct test of the NMN-plus-resveratrol pairing found: in healthy mice the combination raised NAD+ 1.59-fold in heart and 1.72-fold in skeletal muscle compared with NMN alone (both p<0.001). Joint tissue was not among the six tissues measured.

Population

Healthy young male mice; NAD+ measured in brain, heart, kidney, liver, lung and muscle

Intervention

A single oral dose of NMN 500 mg/kg plus resveratrol 50 mg/kg (or ginsenosides Rh2&Rg3), sampled at 1, 2, 4 and 6 hours

Comparator

Oral NMN alone

Limitations

One oral dose followed for six hours in three animals per group per timepoint; the authors name that sample size as a limit on their own statistics. Healthy young mice, no disease model, no functional endpoint, and nothing measured in cartilage or any joint. The mechanism the authors propose for the combination is labelled speculation in the paper.