Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men

Igarashi M, Nakagawa-Nagahama Y, Miura M, et al. · NPJ Aging

Blood NAD+ and its metabolites rose significantly on NMN; gait speed and left-hand grip strength showed only nominally significant improvements the authors themselves flag as needing validation, and body composition did not change. No joint outcomes were measured.

Population

Healthy men aged 65 or older

Intervention

NMN 250 mg/day orally for 6 or 12 weeks

Comparator

Placebo

Limitations

Three authors are employees of Mitsubishi Corporation Life Sciences (the NMN supplier); data from 22 of the 42 randomized participants were excluded from analyses because of an error in distributing NMN and placebo, which the authors note disrupted the baseline adjustment between groups.