Microfragmented Adipose Tissue Versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Prospective Randomized Controlled Trial at 2-Year Follow-up

Zaffagnini S, Andriolo L, Boffa A, et al. · The American Journal of Sports Medicine

Both arms improved significantly and durably to 24 months with no between-group differences; imaging showed no structural change after either injection.

Population

118 patients with symptomatic knee OA

Intervention

Single MFAT injection

Comparator

Platelet-rich plasma

Limitations

No placebo arm; equivalence to PRP does not establish efficacy beyond placebo; no structural benefit on imaging.