Thymosin β4 and prothymosin α promote cardiac regeneration post-ischaemic injury in mice

Gladka MM, Johansen AKZ, van Kampen SJ, Peters MMC, Molenaar B, Versteeg D, Kooijman L, Zentilin L, Giacca M, van Rooij E · Cardiovascular Research

The Tβ4-plus-prothymosin-α combination created a permissive environment for cardiomyocyte proliferation and reduced cardiac dysfunction after ischaemic injury — an independent group recovering a cardiac benefit, though by gene delivery rather than injected peptide.

Population

Mice after ischaemic cardiac injury

Intervention

Viral overexpression of thymosin β4 together with prothymosin α in the myocardial wall

Comparator

Control vector

Limitations

Overexpression of two genes in combination, not administration of Tβ4 protein; effect cannot be attributed to Tβ4 alone.