The association between vitamin K and medial tibial-femoral knee osteoarthritis progression: Data from the osteoarthritis initiative

Horace RW, Roberts M, Lu B, et al. · Osteoarthritis and Cartilage Open

Lower dietary vitamin K was associated with faster loss of quantitative medial tibiofemoral joint space width in a dose-response pattern, with the trend reaching significance in the Kellgren-Lawrence grade 2 stratum (P<0.025) — a fourth cohort pointing the same way as Framingham, MOST and Health ABC.

Population

Osteoarthritis Initiative participants with radiographic knee osteoarthritis, followed to 48 months

Intervention

Baseline dietary vitamin K by brief food-frequency questionnaire

Comparator

Higher versus lower intake

Limitations

Observational, with a brief food-frequency questionnaire measuring mostly K1; the overall association is carried by one radiographic grade stratum; the authors call for replication. NIH-funded; no competing interests.