Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Dehzad MJ, Ghalandari H, Nouri M, Askarpour M · Cytokine

Pooled reductions in CRP (-0.58 mg/L, 95% CI -0.74 to -0.41), TNF-alpha (-3.48 pg/mL) and IL-6 (-1.31 pg/mL), with no change in IL-1beta; total antioxidant capacity rose and malondialdehyde fell.

Population

66 RCTs of turmeric or curcumin supplementation in adults

Intervention

Turmeric or curcumin supplementation

Comparator

Placebo or control

Limitations

The pooled effect sizes are small in absolute terms and the trial base is dominated by short studies in metabolic populations; GRADE certainty varied by outcome, and the earlier disease-restricted meta-analysis (pmid-31121255) found nothing.