Pharmacokinetics and Pharmacodynamics of Anthocyanins after Administration of Tart Cherry Juice to Individuals with Gout

Brunetti L, Wang L, Wassef A, Gong Y, Brinker A, Buckley B, Lipsky PE, Ondar P, Poiani G, Zhao L, Kong AN, Schlesinger N · Molecular Nutrition & Food Research

Measures what actually enters circulation after drinking the juice, which most cherry trials assume rather than check: cherry anthocyanins are absorbed, but reach plasma at very low concentrations and clear quickly, with metabolites rather than parent anthocyanins accounting for most exposure.

Population

Adults with gout

Intervention

Tart cherry juice, with serial blood and urine sampling

Comparator

None (within-subject pharmacokinetics)

Limitations

Twelve people, no control arm, and pharmacokinetics only — it establishes exposure, not effect.