The effect of pentosan polysulfate sodium for improving dyslipidaemia and knee pain in people with knee osteoarthritis: A pilot study

Liu X, Virk S, Fedorova T, et al. · Osteoarthritis and Cartilage Open

Knee pain NRS fell from 6.4 to ~4.2–4.4 and LDL modestly decreased, but with no placebo arm the pain result is uninterpretable given OA's large placebo response.

Population

Adults with knee OA plus hypercholesterolemia

Intervention

Oral PPS 10 mg/kg every 4 days, two 5-week cycles

Comparator

None (single-arm, open-label)

Limitations

Uncontrolled, open-label, small; pain was a secondary outcome.