Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters

Khavinson VK, Linkova NS, Rudskoy AI, Petukhov MG · Biomolecules

The 26 active peptides scored better than the unselected di- and tripeptides at all four transporters. AED itself ranked mid-pack — 14th of 26 at LAT1, 12th at LAT2, 13th at PEPT1 — and the peptides the paper singles out as the strongest ligands are EDR, EDG, AEDR and KEDP rather than AED.

Population

Computational docking of 26 ultrashort peptides, including AED, against LAT1, LAT2, PEPT1 and PEPT2

Intervention

Molecular modelling and ligand docking, benchmarked against all 8400 possible di- and tripeptides

Comparator

Di- and tripeptides with no established biological activity, and known transporter substrates

Limitations

Docking scores are a computed binding estimate, not measured transport; no cell, tissue or plasma measurement was made, and the paper does not address whether an oral dose survives digestion. Institute-authored; full text read via PMC10046148.