Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues

Smith MM, Melrose J · Pharmaceuticals (Basel)

Modern mechanism catalogue: decades of clinical deployment in cystitis and painful bowel disease, protease inhibition in cartilage and disc, complement and coagulation regulation, hyaluronan stimulation, suppression of osteocyte nerve-growth-factor production (a proposed OA-pain mechanism), and clearance of lipid from subchondral blood vessels.

Population

Narrative review of PPS biology across tissues

Intervention

n/a

Comparator

n/a

Limitations

One author is clinical research director at Arthropharm, a PPS company, and the other has taken its consultancy fees, disclosed in the acknowledgements while the conflict statement declares none; a mechanism catalogue that cites a single case report as its human bone-marrow-lesion evidence, not an outcomes assessment.