Peptide Regulation of Chondrogenic Stem Cell Differentiation

Linkova N, Khavinson V, Diatlova A, Myakisheva S, Ryzhak G · International Journal of Molecular Sciences

The institute's own English-language review names the growth-factor-derived (B2A, SK2.1, SSPEPS) and cartilage-matrix-derived peptides (LPP, GFOGER, collagen-mimetic, RGD, N-cadherin mimetic) as the most promising for chondrogenesis, and places its own AED peptide in the summary table on gene-expression evidence alone. It states that the cartilage polypeptide complex contains short peptides of 75–846 Da including AED, and that the complex is in phase-2 trials for osteoarthritis in Russia.

Population

Narrative review of peptides that regulate chondrogenic differentiation of mesenchymal stem cells

Intervention

n/a

Comparator

n/a

Limitations

Institute-authored narrative review with no protocol or search strategy; the phase-2 trial claim and the 75–846 Da composition figure are sourced to a Eurasian patent and to a Russian-language journal that PubMed does not index; full text read via PMC10179481.